Conference publications

Abstracts

XVIII conference

Modeling of Macromolecular Transport in a Dynamically Loaded Biological Tissue

Akhmanova M.A., Domogatsky S.P.¹

Lomonosov Moscow State University, Physics Dept., 119991, Moscow, Leninskie Gory, GSP-1, E-mail: maria.akhmanova@gmail.com

¹Russian Cardiology Research Center MHSD RF, 121552, Moscow, 3rd Cherepkovskaya str. b. 15a, spdomo@gmail.com, +7(495)4146950     

1 pp. (accepted)

Artificial implants are usually connected with soft biological tissue. External mechanical loading induce fluid flow within tissue, which is important stimuli for cells, governing the rate of their biosynthesis and even differentiation, and in turn promoting osseointegration of implant[1]. It is hypothesized that cyclic loading can enhance solute transport in biological tissues, and through this mechanism improve tissue nutrition or response to regeneration factors. The existing experimental data that support this statement is limited, and obtained mainly on cartilage samples. The other aspect in this context that remain obscure is how binding of macromolecules to extracellular matrix influence their transport, induced by loading, although most proteins and signaling molecules has the ability to adhere or bind to matrix components. The objective of this study is to examine effect of cyclic loading theoretically and to investigate at what conditions convective transport induced by dynamic loading might significantly alter solute accumulation, taking into account reversible binding of solute to polymer matrix.

References

1. P.J. Prendergast, H.W.J. Huiskes, K. Søballe, Biophysical stimuli on cells during tissue differentiation at implant interfaces// J. Biomech., 30, 1997, pp. 539-548

• view as PDF