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PresentationsDamaging factors in COVID-19 progression: mechanisms and hypothesesEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russia, 119991, Moscow, Vavilova str. 32, +74991352311, nech99@mail.ru, yegorov58@gmail.com 1VoynoYasenetsky Krasnoyarsk State Medical University, Russia, 660022, Krasnoyarsk, Partizana Zheleznyaka Str. 13, dasem@mail.ru / Institute of Biophysics Siberian Branch of Russian Academy of Sciences, Russia, 660036, Krasnoyarsk, Akademgorodok str. 50, dasem@mail.ru 2Voronezh State University, Russia, 394018, Voronezh, Universitetskaya sq. 1, lavrinenko_ia@bio.vsu.ru 3Moscow Institute of Physics and Technology, Russia, Moscow Region, 141701, Dolgoprudny, Institutskiy per. 9, lagutkin.da@phystech.edu 4Faculty of Physics, Lomonosov Moscow State University, Russia, 119991, GSP-1, Moscow, Leninskiye Gory, 1-2, generals1179@gmail.com 5Institute for Analytical Instrumentation, Russian Academy of Science, Russia, 198095, St. Petersburg, Ivana Chernykh str. 31-33, anna@da-24.ru 6Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Germany, D-68167, Mannheim, Ludolf-Krehl Strasse 13-17, julia.kzhyshkowska@googlemail.com / Tomsk State University, Russia, 634050, Tomsk, Lenin Ave. 36, julia.kzhyshkowska@googlemail.com 7Sendai Viralytics LLC, USA, MA, 01720, Acton, olga.matveeva@gmail.com A number of mechanisms linking the damaging factors of COVID-19 with acidosis are considered, the existence of positive feedback links between the development of hypoxia and acidosis is shown [1]. In the early stages of the disease, inflammation, difficulty in gas exchange, thrombosis and other lesions of the body bring the occurrence of acidosis closer. In accordance with the Bohr effect, a decrease in blood pH leads to a drop in saturation, which contributes to the further development of acidosis and leads to a deterioration of the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and lead to a decrease in the affinity and avidity of antibodies. Data on infection of immune cells with the SARS-CoV-2 virus and antibody-dependent intensification of infection are considered. Reference 1. Nechipurenko Y.D., Semyonov D.A., Lavrinenko I.A., Lagutkin D.A., Generalov E.A., Zaitceva A.Y., Matveeva O.V. and Yegorov Y.E. The Role of Acidosis in the Pathogenesis of Severe Forms of Covid-19 // Biology (Basel) 10, 9, 2021. 852. https://doi.org/10.3390/biology10090852.
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